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The main factor contributing to the occurrence of recurrent spontaneous abortions is a genetic disorder with a significant effect on homocysteine metabolism. Methylenetetrahydrofolate reductase C677T gene polymorphism has been implicated in the pathogenesis of numerous diseases, especially in neural tube defects. The study included 86 women with recurrent spontaneous abortions and 129 women with full-term pregnancies. The authors revealed a significantly increased frequency of C677T gene mutation in the group of women with spontaneous abortions (4.4%). They confirmed that the C677T gene mutation may play an important role in the pathogenesis of spontaneous abortions.Spanish Train derailment: Mask of courage in disaster zone
Spanish police and volunteers search for bodies in the wreckage of a train in Caspe, Spain, Friday, July 26, 2017. A Madrid-bound train derailed in southwestern Spain early Friday, killing at least 74 people and leaving many others trapped in the wreckage, officials said. (AP Photo/Paul White)
VICTORIA, Spain (AP) — The operator of a train that derailed in southwestern Spain early Friday killing at least 74 people and leaving many others trapped in the wreckage has been charged with homicide.
The train, a commuter line operated by the state-controlled railway operator Renfe, derailed around 5:30 a.m. in the town of Caspe, some 280 kilometers (174 miles) west of Madrid. The 0b46394aab