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[The Yucatan nursery rat (Rattus rattus c.s.) as an emerging model for the study of infection by Toxoplasma gondii in the CNS].
The Yucatan rat (Rattus rattus) has been shown to be an established experimental model for a neuroinfection by Toxoplasma gondii. The population dynamics and final size of an acute infection in the brain and cerebellum of this strain of rats were studied. Parasite multiplication was greater in the brain than in the cerebellum, the parasite tachyzoite density reached a peak at three days after infection and thereafter decreased. Brain showed more inflammatory cells than the cerebellum. By day 20 post-infection, the parasite tachyzoite density was reduced to levels found in control animals and neutrophilic infiltration was also reduced. The cerebellum was mainly infected and the tachyzoite density significantly decreased at day 20. Neutrophilic infiltration was more intense in the cerebellum than in the brain. In conclusion, at day 20 post-infection, the major portion of tachyzoites is localized in the brain. Microglial cell activation and inflammatory cell infiltration are more intense in the brain than in the cerebellum. By using the Yucatan rat as an experimental model, the impact of an immuno-therapy 0b46394aab
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